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'If I cannot access services then there is no reason for me to test': the impact of health service charges on HIV testing and treatment amongst migrants in England

Policy governing entitlement to access government health care for foreign nationals in England is a subject of debate, controversy and confusion. Of particular concern to health providers has been the impact of National Health Service charges on delaying HIV testing and anti-retroviral treatment uptake and adherence amongst certain migrant groups. Data obtained through focus groups with 70 migrants from southern Africa, suggest that confusion over health care entitlements exists amongst those seeking health care and is reported amongst health service providers. This confusion, as well as financial difficulties and fears over deportation facing some migrants, can in turn be a factor influencing their decisions to avoid formal health services, resort to alternative and often ineffective or potentially adverse forms of therapy, and delay HIV testing and treatment uptake

Quasi-experimental study designs series –Paper 9: Collecting Data from Quasi-Experimental Studies

Objective: To identify variables that must be coded when synthesizing primary studies that use quasi-experimental designs.  Study Design and Setting: All quasi-experimental (QE) designs.  Results: When designing a systematic review of QE studies potential sources of heterogeneity – both theory-based and methodological – must be identified. We outline key components of inclusion criteria for syntheses of quasi-experimental studies. We provide recommendations for coding content-relevant and methodological variables, and outlined the distinction between bivariate effect sizes and partial (i.e., adjusted) effect sizes. Designs used and controls employed are viewed as of greatest importance. Potential sources of bias and confounding are also addressed.  Conclusion: Careful consideration must be given to inclusion criteria and the coding of theoretical and methodological variables during the design phase of a synthesis of quasi-experimental studies. The success of the meta-regression analysis relies on the data available to the meta-analyst. Omission of critical moderator variables (i.e., effect modifiers) will undermine the conclusions of a meta-analysis

ERA: On-the-fly networking for collaborative geology fieldwork

BACKGROUND Field-based activities are regarded as essential to the development of a range of professional and personal skills for undergraduate students within geography, earth and environmental sciences. Students are taught investigative skills to enable them to interpret features within the landscape, establish technical skills such as sketching and the use of field equipment, and learn to collaborate with peers. Students enjoy field activities, and these improve deeper learning and understanding. However, due to issues such as cost and access some have little opportunity to participate in field-based studies. The ERA (Enabling Remote Activity) project is investigating how mobile and communication technologies might enhance field learning experiences for all participants. We identify two ways in which supporting technologies can enable greater participation and add value to existing fieldwork: remote access and collaborative groupwork. METHODS In 2006 we enabled a single mobility impaired student to direct a remote geologist in the field, supporting remote access. A rapidly deployable, lightweight, battery powered wireless network was built (which we refer to as an ‘on-the fly network’) to enable the transmission of video, audio, and high resolution still images from the field to the student. In 2007 we supported three groups of volunteers undertaking remote collaboration, with half the participants in a university laboratory and the others in the field location. Each group was carrying out a separate specific geological investigation; graphic logging, paleontology, or mineralogy and paleocurrents. A network infrastructure supported communication and data transmission between the groups. Field and laboratory participants had their own distinct, significant roles and the trials explored how technology enhanced collaboration may be used to improve student learning. CONTRIBUTION ERA has tested highly mobile, easily configurable low cost network tools to explore how on-the-fly networking can support geology field studies at undergraduate level in remote locations. We have explored two differing configurations, developed through a collaborative design process undertaken between technology developers and course managers. EVALUATION AND REFLECTION A range of evaluation tools were used to enable analysis of the trials. Field journals were kept by all participants, which found ready acceptance with the geologists as an extension of their standard practice of keeping field notes. A wiki was used by the technical team to capture lessons learnt during the development and trial periods. Participants were gathered together for post-trial debrief sessions. In the second trial, participants’ responses were collected through written questionnaires and focus group discussions (audio recorded). Participants’ activities were also captured on video camera and this was analysed to capture critical incidents. Key findings underline the importance of co-designing technology and pedagogy, orchestration of multiple groups, on-site testing, and planning for graceful degradation of technologies and learning activities. In 2008 we will be looking to move the system from a development prototype to a production model that could be could be replicated by geology departments across the UK without intensive technical support, and the proving of specific technical enhancements including VOIP (Voice Over Internet Protocol) communication and the use of wireless digital cameras

Quasi-experimental study designs series – Paper 10: Synthesizing evidence for effects collected from quasi-experimental studies presents surmountable challenges

Objective: To outline issues of importance to analytic approaches to the synthesis of quasi-experiments (QEs), and to provide a statistical model for use in analysis. Study Design and Setting: We drew on the literatures of statistics, epidemiology, and social-science methodology to outline methods for synthesis of QE studies. The design and conduct of quasi-experiments, effect sizes from QEs, and moderator variables for the analysis of those effect sizes were discussed. Results: Biases, confounding, design complexities and comparisons across designs offer serious challenges to syntheses of QEs. Key components of meta-analyses of QEs were identified, including the aspects of QE study design to be coded and analyzed. Of utmost importance are the design and statistical controls implemented in the QEs. Such controls and any potential sources of bias and confounding must be modeled in analyses, along with aspects of the interventions and populations studied. Because of such controls, effect sizes from QEs are more complex than those from randomized experiments. A statistical meta-regression model that incorporates important features of the QEs under review was presented. Conclusion: Meta-analyses of quasi-experiments provide particular challenges, but thorough coding of intervention characteristics and study methods, along with careful analysis, should allow for sound inferences

“A Supernova that Sparks in Every Direction”: A Long-Term Assessment of the Research Sprints Faculty Engagement Program

Article will be published in College & Research Libraries in March 2024. This is the accepted version of the manuscript prior to copyediting.PREPRINT: Article to be published in College & Research Libraries in March 2024. This is the accepted version of the manuscript prior to copyediting. The Research Sprints program offers faculty partners the opportunity to collaborate intensively and exclusively for one week with a team of librarians to achieve significant progress on research or teaching projects. This longitudinal study extends previous immediate and short-term assessments by interviewing Research Sprints participants at two research-intensive institutions 2-4 years after their concentrated week. The authors evaluate the enduring impact of the program on the participants’ projects, research/teaching practices, and relationships with the library. Participants report achieving project goals, improved skills and student success, and greater awareness and appreciation of librarians’ work

Rising public expenditure and economic growth, was Wagner right? Evidence from Nigeria

This study empirically tests if the Wagner’s law stands for the Nigerian economy using data for the period 1981-2015. Form the results, economic, social and community services expenditure show highly significant values suggesting that these sectors are very much needed and still adds value to the economy. The results of the Granger causality analysis indicates that there is a bi-directional causality between economic growth and government spending, which posit to a high level of accuracy that Wagner’s law holds for Nigeria. The result suggests that economic growth has an important role to play in determining government spending because as the economy grows, it expands and for this, government need to expand its spending to meet up with the demands of the expansion. There is therefore the need for curtail the rapid growth of its size above the optimum level that stimulates rise in expenditure. Any further expansion in expenditure should focus on economic, social and community services since they are growth enhancing

Behind the Screen : Commercial Sex, Digital Spaces and Working Online, Technology in Society

The rise of the internet and related digital technologies has had a profound impact on many aspects of people’s working and social lives, including the buying and selling of sexual services. In addition to providing new ways to advertise for sex workers who provide services to clients in person, the internet has also seen the development of completely new forms of commercial sex (like webcamming) that take place entirely in an online environment. Using the largest datasets created in the UK/Europe, this article explores how sex workers use the internet and digital technologies to facilitate the range of different services that they offer. We identify the ways in which the internet has improved the ability for sex workers to organize and professionalize their services, with increasing profit and safety being core objectives. At the same time, we explore some of the challenges and potential (new) harms that arise for sex workers working online. In this paper, we aim to explore the diversity of ways in which sex workers interact with online and digital technology. This paper advances knowledge by: a) demonstrating how the shift to online working developed for sex workers and their views on the importance of the internet to their working lives; b) exposing the different marketing strategies adopted by sex workers, including the use of social media and personal websites in building an online brand; and c) discussing the impact of online reviews and the wider culture of reviewing commercial sexual services

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.

BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (DSBs), mediators including ATM are recruited to the site of DNA-damage. Subsequent phosphorylation of p53 by ATM and ATM-induced CHK2 results in p53 stabilization, ultimately intensifying transcription of p53-responsive genes involved in DNA repair, cell-cycle checkpoint control and apoptosis. METHODS: In the current study, we investigated the stabilization and activation of p53 and associated DDR proteins in response to treatment of human colorectal cancer cells (HCT116p53+/+) with the MDM2 antagonist, Nutlin-3. RESULTS: Using immunoblotting, Nutlin-3 was observed to stabilize p53, and activate p53 target proteins. Unexpectedly, Nutlin-3 also mediated phosphorylation of p53 at key DNA-damage-specific serine residues (Ser15, 20 and 37). Furthermore, Nutlin-3 induced activation of CHK2 and ATM - proteins required for DNA-damage-dependent phosphorylation and activation of p53, and the phosphorylation of BRCA1 and H2AX - proteins known to be activated specifically in response to DNA damage. Indeed, using immunofluorescent labeling, Nutlin-3 was seen to induce formation of γH2AX foci, an early hallmark of the DDR. Moreover, Nutlin-3 induced phosphorylation of key DDR proteins, initiated cell cycle arrest and led to formation of γH2AX foci in cells lacking p53, whilst γH2AX foci were also noted in MDM2-deficient cells. CONCLUSION: To our knowledge, this is the first solid evidence showing a secondary role for Nutlin-3 as a DDR triggering agent, independent of p53 status, and unrelated to its role as an MDM2 antagonist